AARDEX Group

AARDEX Group News and Views

AARDEX Group Blog

In a world where clinical trials can make or break the success of a new medication, there's one critical factor that can't be overlooked: medication adherence. That's where our blog comes in. We're here to provide you with the latest industry news, practical tips, and expert advice on everything related to medication adherence in trials.

AARDEX Group Blog

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In observance of Rare Disease Day, it is imperative to underscore the progressive strides within the domain of rare disease research. Rare diseases, characterized by their infrequent occurrence within the general populace, impose significant burdens not only on the affected

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Approaches to Medication Adherence

It is human nature for people to trust the things that are known to them ahead of the things that are not. Familiarity, after all, brings with it a sense of comfort and reassurance. It is perhaps understandable, therefore, that

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Ignorance of ALCOA+ is a Risk to Regulatory Compliance

In this article, AARDEX Group Quality Manager, Oana Paun, discusses ALCOA+ and its importance for achieving regulatory compliance. For those with a scientific ear, it can be reassuring when you hear ideas discussed in terms of data. The word alone

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The list of Neurological conditions is considerable, with epilepsy, Alzheimer’s disease, dementia, stroke, migraine, multiple sclerosis, Parkinson’s disease, neuro infections, and brain tumors, all attributed to this category of disease. Hundreds of millions of people worldwide are affected by neurological

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Bias in clinical Research

It’s an uncomfortable truth that decision-making is a murky business. While we would all like to think that our actions and the choices underpinning them are rooted in logic, integrity, and reason, the truth is not entirely clear-cut. In reality,

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Dose Optimization

In this article, Dr. Vrijens shares his thoughts on the need for dose optimization in the interests of balancing safety and efficacy. How we use language has a huge bearing on the meaning we convey. Take the word ‘overdose’, for

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Medication Adherence Data

In this article, Dr. Bernard Vrijens discusses the importance of medication adherence data in clinical trials and why medication adherence should be a calculation, not an estimation. The world is today collecting a mind-blowing amount of data. Indeed, IDC calculates that about

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Medication Non-Adherence

In this article, our Scientific Lead, Bernard Vrijens, discusses the influence of medication non-adherence on ROI in clinical trials. Get ready for an insightful read! Fraught with risk yet pivotal to the future success of a drug candidate, clinical trials

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Patient Medication Information

This action, if finalized, will require applicants to create a new type of medication guide, referred to as Patient Medication Information (PMI). In this article, our Scientific Lead, Bernard Vrijens, unpacks the proposals and questions whether more is needed to

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CancerX

Adherence specialists join multi-stakeholder CancerX initiative to improve long-term pathways for cancer patients and meet the challenge of oral treatments. Liege, Belgium- July 18, 2023: Adherence specialist AARDEX Group is proud to announce it is a founding member of the CancerX initiative, bringing

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In recent decades we have witnessed a shift in how chemotherapy drugs are administered. Historically, cytotoxic chemotherapies were almost exclusively administered by a healthcare professional (HCP) via injection or intravenous drip, but today, oral chemotherapy drug forms are becoming increasingly

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Integration of AARDEX MEMS AS and MEMS Mobile technology with Mevia’s Medose dispenser offers opportunity to pilot next stage in reusable and real-time adherence solutions. Liege, Belgium- June 8th, 2023: Adherence specialist AARDEX Group is proud to announce its partnership with Mevia, a

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DiMe Digital Medicine Society

Extending the Verification, Analytical Validation and Clinical Validation (V3+) Framework Project will ensure digital clinical measures and products meet the needs of larger audiences. Liege, Belgium- May 3, 2023: Adherence specialists AARDEX Group is proud to announce its partnership with other industry leaders

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Outsourcing in Clinical Trials Europe (1)

Exciting news! AARDEX Group is gearing up for one of the most highly anticipated events in the clinical trials industry – the 13th Annual Outsourcing in Clinical Trials Europe conference, which will take place in the beautiful city of Barcelona

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Pill Count Compliance It's Time to Burst the Drug Trial Bubble

In this article, our Scientific Lead and Adherence Expert, Bernard Vrijens, explores the use of pill count compliance in clinical trials and its reliability for measuring medication adherence. Pressure is ubiquitous when it comes to conducting clinical trials. Sponsors feel the

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Job van Boven

Dr. Job van Boven, Associate Professor at the University Medical Center Groningen, shares his invaluable insights on the evolution of medication adherence monitoring solutions.  According to Dr. Job van Boven, Associate Professor at the University Medical Center Groningen, Founding Director of

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About the CMO Step-Up Challenge What is the #CMOStepUp Challenge all about, you may ask? It’s a step challenge where participants will compete to clock the most steps and emerge victorious with the Meta Quest VR Headset as their reward.

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Greetings and salutations! It’s time for the March issue of the Medication Monitoring Matters newsletter, where we delve into cutting-edge advancements in medication adherence monitoring. In this edition, we’ll examine the potential downsides of Video Directly Observed Therapy (VDOT) as

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Drug trials are conducted to evaluate the safety and efficacy of new or investigational drugs. The primary goal of drug trials is to determine if a new drug is effective in treating a particular medical condition and if it is

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In clinical trial analysis, it’s assumed that participants are following the instructions for the investigational product. Unfortunately, the evidence suggests that this is far from reality. Recently, Kenneth Getz, Executive Director and Professor at the Tufts Center for the Study

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“Objective and granular” digital adherence measures could improve trial efficiency and allow for better-informed decisions on the efficacy and safety of new drug products. That’s according to the authors of a literature review that looked at more than 100 medicines

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Greetings from the forefront of innovation in clinical trials. We’re thrilled to introduce you to the first edition of our medication adherence newsletter, Medication Monitoring Matters. Our focus? Empowering clinical trial sponsors like you to elevate the standard of care

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With the current push for increased diversity in research, the medical community has accepted the challenge to make trial populations more representative of those in clinical practice. Yet poor medication adherence, which clouds the view of how drugs work in

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Seamless integration of adherence and research data protects participant safety and data quality, with no additional burden for clinical trial sites or participants Liege, Belgium- February 2, 2023: Adherence specialists AARDEX Group and remote research platform experts in the Clinpal team at Cambridge Cognition have teamed up

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Poor medication adherence during clinical trials can skew results, leading to underestimations of product efficacy, inaccurate pharmacokinetic/pharmacodynamic calculations, and even put participant safety at risk.1 Research has shown that up to 50% of people who take part in drug development

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The World Health Organization (WHO) has recently highlighted how poor adherence can lead to poorer outcomes for prisoners, contributing to health inequalities the world over. But it is worth noting that near-perfect adherence can be just as troublesome within the

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Poor adherence to the investigational product can bring even the most carefully planned clinical trial to its knees. It is time to accept that traditional approaches such a pill count do not work. We need to upset the status quo

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Belgium – medmix Drug Delivery (Haselmeier) and AARDEX Group announced today a collaboration, combining Haselmeier´s D-Flex™ Logbook with AARDEX Group’s Medication Adherence software and hardware ecosystem.  Clinical testing during new drug development is costly and time intensive for pharmaceutical and

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Poor medication adherence in clinical trials may be a long-standing challenge, but advanced approaches and technologies are finally cutting it down to size. Join AARDEX’s scientific lead at the 21st Clinical Trials Europe event to find out how. Bernard Vrijens and

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Adherence to medication during clinical trials is a problem of striking magnitude, and one that researchers have employed therapeutic drug monitoring (TDM) to solve for years. But the approach, which measures the level drug or drug metabolites in patients’ blood,

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Every clinical trial participant with poor medication adherence will have their own set of complex reasons for not taking their medications as prescribed – meaning there is no one size fits all solution. Instead, sponsors should take a data-driven approach

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When clinical trial participants do not follow the dosing protocol, it can result in an underestimation of a drug’s therapeutic effect. With inability to demonstrate efficacy being the leading cause of study failure worldwide1, it’s an issue sponsors cannot afford

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While digital pills have long been hailed as a valuable solution to the stubborn medication adherence problem, there have been questions about their use, in terms of intrusiveness, acceptance, and reliability. But with the evidence base expanding, there are opportunities

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Even the most efficacious medicines do not work when people don’t take them – and the same is true for digital medication adherence monitoring. Because while the approach has huge potential in clinical trials and routine practice alike, embracing the

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Digital health technologies (DHT), including digital medication adherence monitoring, have the potential to revolutionize drug development, and must be given every opportunity to succeed.  That’s according to the European Federation of Pharmaceutical Industries and Associations (EFPIA) reflection paper, which has

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Proving the efficacy of investigational products is a complex process but with the right Medication Adherence Technology, sponsors can generate the evidence that they need to get drugs from labs to life, faster. Unmet Medical Need Non-steroidal anti-inflammatory drugs (NSAIDs)

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Drug giant, Pfizer has highlighted the need for effective, patient-centered medication adherence management in clinical trials. Nothing stops a drug from working more than not taking it, but, as medicine and leadership pioneer and Pfizer’s Chief Medical Officer, said, non-adherence

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Combining BIOCORP’s pen injector add-on with AARDEX® Group’s Software to improve adherence to medication in a Hybrid Phase IV Diabetes Study. Liege, Belgium – July 19, 2022: Following the launch of their global collaboration to support medication adherence in different fields last

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Electronic Medication Monitoring

Effectively measuring medication adherence relies on selecting the most appropriate data source – and for clinical trials, that data source is electronic medication monitoring. The TEOS (timelines-events-objectives-source) guideline provides a clear framework on how to assess medicine-taking behavior relative to

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Patient Adherence Behaviors

Realizing the potential of the revolution in cancer treatment depends on ensuring researchers, regulators, and clinicians have access to all the information they need to develop, approve, and prescribe new drugs – including patient adherence data. Nothing stops a drug

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Smart Caps Improve Patient Adherence

Poor medication adherence is a problem that has gone “unsolved” for decades. But combining smart caps with individualized feedback can drive the adherence that proves the investigational product efficacy and underwrites approvals. In this case study, we set out the

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Measure Medication Adherence

The emergence of pharmacogenomics is an important milestone in the precision medicine journey – but the importance of measuring medicine adherence, an essential component in the complex pharmacokinetics/ pharmacodynamics equation, can often be overlooked. In this article, Bernard Vrijens, CEO

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May 2022 News

Welcome to the May edition of AARDEX Group’s Clinical Trials and Tribulations Newsletter – an aggregated collective of all of the industry’s hottest news and views!  Breaking News New Pivotal Data Demonstrates the Clinical Benefit of Roche’s glofitamab, a Potential

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Poor Patient Adherence

The emergence of outcome-based contracts in clinical research has placed an additional consideration on the already thorny issue of adherence. When drug companies are paid according to the real-world effectiveness of their products, ensuring people take the medications as prescribed

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Adherence to Medication

If enacted, the US’ Right Drug Dose Now Act will place pharmacogenomics on the main stage of drug development and move us further into the personalized medicine era. By supporting the use of pharmacogenetic testing to prevent adverse events (AEs)

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smart pill bottles

“Nothing stops a drug from working like not taking it, making patient adherence one of the most important factors to consider when designing a clinical trial.”  – Bernard Vrijens, Scientific Lead, AARDEX® Group Poor patient adherence is a problem that has

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The Role of Medication Adherence Tools

Despite huge strides in how cardiovascular diseases (CVD) are treated in recent years, the conditions remain among the leading causes of morbidity and mortality worldwide. At least part of the problem is that even the most effective drugs will not

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Smart Pills

The partnership sees the integration of AARDEX’s adherence analytics software with etectRx’s ingestible adherence sensor smart pill. Liege, Belgium (APRIL 28, 2022) – Belgium-based AARDEX Group, the leader in measuring and managing medication adherence in clinical trials today announced a strategic

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Drug Forgiveness and Patient Adherence

With patient adherence thought to be lower than 50% 1, drug companies are increasingly maximizing dosages to bridge the gap at population scale – but are we overdosing individual patients as a result? The industry’s tendency to always aim for the

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FDA Diversity Guidance

Diversity in clinical research is a growing concern for sponsors as many factors can influence how an individual may react to certain drugs: age, biological sex, disabilities, chronic comorbidities, geographical location, gender identity, race, and ethnic background.  Thus, if the

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Protocol Deviations in Decentralized Trials

Decentralized Clinical Trials (DCTs) are here to stay, as demonstrated by international regulators’ recent commitments to the model. But while the approach offers a multitude of benefits, from expanding access to increasing cohort diversity, it can also serve to magnify

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In a world of big tech, data is king. This slogan is far from news for the Biopharmaceutical Industry, but clinical trials are lengthy, complex, and expensive, meaning precious information isn’t always utilized to its maximum potential. In recent years,

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FDA DHT Guidance | AARDEX Industry Insights

It’s hard to believe that we are already a full quarter into 2022 – and a busy one it’s been -particularly for the regulatory landscape. AARDEX® Group also announced the first in a series of virtual events, a live panel debate

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FDA DHT Guidance

In December last year, the Food and Drug Administration (FDA) issued new draft guidance (Digital Health Technologies for Remote Data Acquisition in Clinical investigations) on what kinds of devices and software may be used for remote monitoring of clinical trial

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innovative health initiative

Technology presents the healthcare community with a golden opportunity to improve lives – but only if we embrace that potential. Success, according to the Innovative Health Initiative’s Strategic Research and Innovation Agenda, depends on cross-sector collaboration. Across Europe, healthcare faces

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Clinical research can stand or fall on the adherence to trial medications – even the most efficacious interventions will fail if people do not take their medicines as prescribed. That’s why researchers from the University of Sydney and the University

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FDA Issues Proposed Guidance for the use of Digital Health Technology in Clinical Investigations

In recent years, a multitude of Digital Health Technologies (DHTs) have emerged, many with the ability to solve some of the biggest problems in clinical trials. However, uptake has been slow.  Now, proposed new Food and Drug Administration (FDA) guidelines

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Paving the way for patient adherence in clinical trials

For far too long, poor patient adherence has been the elephant in the room. The common, age-old problem has the potential to bring a clinical trial to its knees, and yet with no workable solution on the table, sponsors and CROs have

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Case for Measuring and Managing Patient Adherence

According to the World Health Organization, up to half of the patients with chronic diseases fail to take their medications properly.1 Research shows many patients who are part of clinical trials do not maintain medication adherence either.2 Among many things, poor patient adherence

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Removing the Barriers that Hinder Patient Adherence in Trials

Poor patient adherence tends to be a matter of people not taking their medicine as prescribed, due to access barriers. So how can placing an additional burden on patients be the answer?  As an industry, we are more than aware

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Innovative medication adherence tools in a real-world hospital setting to reduce anxiety in users of mental health services. Liege, Belgium – March 3, 2022: Belgium-based AARDEX Group, the global leader in Digital Tools for measuring and managing adherence to medication, today announced they have

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EU Clinical Trials Regulation

Recent advances in medical science are providing new hope for people living with unmet needs – but modern medicines are only one side of the coin. Ensuring new treatments move from bench side to bedside as soon as possible is

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smart packaging in clinical trials

Poor adherence to medication has been costing lives and money for decades – but cutting-edge solutions are now on hand to solve the age-old problem. It is no secret that the medical community has a problem with patient compliance: patients

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It may hold the potential to solve one of healthcare’s biggest problems, but not all Medication Adherence Tools are created equal. The key to helping people to take their medicines as prescribed, whether within a clinical trial or as part

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When it comes to medication adherence in psychiatry and oncology trials, the stakes are high – not taking medicines as prescribed can have life-altering or even life-threatening consequences. As such, we often assume almost perfect adherence. Unfortunately, this could not

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Boost clinical trial retention with participant engagement and adherence patterns Clinical trial participants are among a study’s most valuable assets – which is why Sponsors & CROs are increasingly investing to keep them on board, on track, and on the

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Ensuring Optimal Medication Adherence Monitoring

It’s no secret, recruiting clinical trial participants is difficult, time-consuming, and considerably expensive, all while dropout rates are notoriously high across therapeutic areas. Whatever the motive for dropout, the impact is huge. Trials can become underpowered and may not have

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Drug development is inherently risky, with some analysis showing that just 13.8% of products that enter industry-sponsored Phase I trials go on to obtain FDA approval.1 Of course, the exact figure varies across therapy areas and development stages, but it is

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Adherence in Decentralized Clinical Trials

Adherence monitoring can minimize variability and maximize engagement in DCTs Decentralized clinical trials (DCT) are growing in popularity, thanks to their ability to tear down many of the long-standing barriers to robust medical research. And while this new model has

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Study power is the Holy Grail of clinical trials, setting drug developers on the quickest path to market – but non-adherence causes costly detours. When participants do not take their medication as specified in the study protocol, it can result

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As we prepare to wrap up the year, we wanted to take an opportunity to reflect on the past twelve months. While COVID-19 had an unprecedented impact on our day-to-day lives, we can take solace in the fact that the

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If 2020 brought the challenges of 21st-century healthcare to the fore, 2021 has been the year of building the case for a new approach.  But as we look ahead to 2022, how can we take what we have learned since

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Medication Adherence: The True Barometer of Patient Engagement

Building sustainable patient-centric trials to weather the storm of COVID-19 involves the utilisation of smart connected devices and packaging to reduce the burden on patients … Read More

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Partnership to Enhance Understanding of Patient Behavior and Opportunities for Early Intervention … Read More

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Data Science and Medication Adherence

Our latest article in Applied Clinical Trials Online discusses the Role of Data Science and Understanding Patient Behavior. … Read More

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This article is taken from Pharmaceutical Manufacturing and Packing Sourcer February 2021, pages 46-49. © Samedan Ltd

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Bernard Vrijens our CEO and Scientific Lead, and Anna-Elisa Hein realizing a master thesis placement at AARDEX Group, conducted a study analyzing the strengths, weaknesses, threats, and opportunities of digital innovation for the personalized management of medication adherence. Anna-Elisa interviewed

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We are soon leaving a very difficult year in all aspects. We lived with global pandemic and civil troubles in the news all year long. However, our Scientific Lead, Bernard Vrijens sees an uptake in remote, decentralized, and hybrid trials.

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AARDEX’s Scientific Lead Bernard Vrijens and Biocorp’s business development director Arnaud Guillet give some details about their companies alliance. They explain how Biocorp’s Injay connected prefilled syringe (PFS) combined with AARDEX’s MEMS Adherence Software provides a mean to tackle the

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Medication adherence, which involves patients taking medications in accordance with how they have been prescribed, is a widespread challenge, with wide-reaching implications for patients and health services worldwide. Managing patient compliance can make the difference between failed and successful clinical

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AARDEX Group, the world leader in medication adherence solutions, today announced a strategic partnership with BIOCORP, a French company specialized in the design, development and manufacture of innovative medical devices. … Read More

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AARDEX is proud to announce the integration of its MEMS® Adherence Software by a major pharmaceutical company. It’s the first end-to-end integration of electronically compiled dosing histories using smart packages from interactive response technology (IRT) into electronical data capture systems

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MEMS® has been a part of successful adherence research for more than 30 years.Download this adherence compendium and find out how digital medication adherence monitoring increases the impact of academic research findings.

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By establishing itself in the U.S., the Group aims to strengthen its business and maintain its position as market leader in digital adherence monitoring systems. Joe Keenan will lead the business development for the pharma and biotech industry in North America.

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Electronic monitoring, a digital technology based on smart packages, enables the most objective and precise adherence monitoring. By using an evidence-based digital adherence monitoring system, Sponsors and HCPs improve drug efficacy by managing patient adherence to the medications. In this

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50 % of patients involved in clinical trials do not take their medication as prescribed, resulting in underestimated drug efficacy and delayed approval of the investigational product. Poor medication adherence is thus a threat to drug development. Stop using unreliable

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The webinar “SMART Medication Adherence Monitoring – Improving Speed and Accuracy of Clinical Trials“, held on April 15, was co-organized with our partner WestRock. Bernard Vrijens, Scientific Lead of AARDEX, has discussed  the challenges of patient non adherence to medications

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Recently, the FDA (Mar 2019) and the EMA (Feb 2020) have finalized guidances to monitor and mitigate the risk of patient non-adherence to the treatments tested in clinical trials. Under the auspices of the International Society for Medication Adherence (ESPACOMP), an

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SRIW, Sowalfin, Noshaq and CCF (Centre de Cautionnement et de Financement du Valais) are now part of the AARDEX Adventure.

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Bernard Duke Video

Medication adherence—the extent to which patients take medications as prescribed in agreement with their health care provider—is an ongoing public health priority, given that improved adherence can lead to better clinical outcomes. … Read More

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AARDEX’s scientific lead Bernard Vrijens is a co-author of the new publication in the Osteoporosis International journal about determinants, consequences and potential solutions to poor adherence to anti-osteoporosis treatment. … Read More

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Aardex Pharma Video

Discover why the Pharmaceutical world trusts us to resolve patient non-compliance. … Read More

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Bernard Vrijens, CEO of AARDEX Group, is invited as a guest speaker at the 2019 annual meeting of the ERS, Madrid, Spain, September 30, 2019. … Read More

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bjcp

Discover our CEO’s last publication in the British Journal of Clinical Pharmacology … Read More

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ascpt

Bernard Vrijens, CEO of AARDEX Group, is invited as a guest speaker at the 2019 … Read More

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blog-image

AARDEX still confirms its leading position in the B2B medication adherence market … Read More

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medication_img

DEC-2018 : Electronic compilation of drug dosing history data using MEMS®Read More

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emerge_img

DEC-2018 : Under the auspices of ESPACOMP, an international panel of experts recently … Read More

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DEC-2018 : With an H-index of 138, AARDEX Group steadily grows its contribution to adherence sciences … Read More

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hypertonie_img

NOV-2018 : Bernard Vrijens, CEO of AARDEX, is an invited speaker at the 42th Annual Conference … Read More

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medicines

NOV-2018 : Bernard Vrijens, CEO of AARDEX, is an invited speaker at the 2nd value added medicines … Read More

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ESPACOMP

OCT-2018 : AARDEX Group will be at ESPACOMP 2018 from November 29th to December … Read More

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savethedate

OCT-2018 : AARDEX group will speak at the Annual Meeting of the American College of Rheumatology … Read More

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ISPOR-Europe

OCT-2018 : AARDEX Group will be at ISPOR Europe in Barcelona 10-14 November 2018. … Read More

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adherence_data

AUG-2018 : Amsterdam, 22nd International AIDS Conference: AARDEX Group presented … Read More

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AUG-2018 : In this groundbreaking publication, the OECD discusses the importance of medication … Read More

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nih_img

JUL-2018 : The National Institutes of Health (NIH) qualified medication adherence … Read More

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FEB-2018 : The Belgian-Swiss company AARDEX Group has announced the completion … Read More

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NOV-2017 : Incredible, one year has already passed since we presented one of the most … Read More

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pill_dump_img

NOV-2017 : Frequently, poor-responders with high pill count adherence are dumping … Read More

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ecosys_img

NOV-2017 : The MEMS® ecosystem is the most versatile medication adherence … Read More

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CDER-Drug-Packaging

OCT-2017 : Want to meet the team behind MEMS®, the original Smart Packages … Read More

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Drug_Discovery

Compelling data presented at the 27th edition of JESFC, Paris, January 13, 2017 … Read More

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adherence_Research-1

clinical studies using MEMS®. Our product bibliography for MEMS® now exceeds … Read More

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adherence_Research

Successful measurement-guided Adherence-enhancing intervention in HIV pre-exposure (PrEP) … Read More

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Clinical-and-research

Best Patient-Focused Technological Development at the First Clinical and Research Excellence … Read More

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mems_system

DEC-2014 : Grant from The Bill & Melinda Gates Foundation to improve adherence … Read More

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