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Poor medication adherence in clinical trials may be a long-standing challenge, but advanced approaches and technologies are finally cutting it down to size. Join AARDEX’s scientific lead at the 21st Clinical Trials Europe event to find out how. Bernard Vrijens and Kenneth Getz, Executive Director and Professor at Tufts Center for the Study of Drug Development…

Adherence to medication during clinical trials is a problem of striking magnitude, and one that researchers have employed therapeutic drug monitoring (TDM) to solve for years. But the approach, which measures the level drug or drug metabolites in patients’ blood, is heavily flawed when it comes to measuring medication adherence. While it is fair to…

Every clinical trial participant with poor medication adherence will have their own set of complex reasons for not taking their medications as prescribed – meaning there is no one size fits all solution. Instead, sponsors should take a data-driven approach that utilizes focused feedback, guides individualized interventions, and has been shown to be capable of…

When clinical trial participants do not follow the dosing protocol, it can result in an underestimation of a drug’s therapeutic effect. With inability to demonstrate efficacy being the leading cause of study failure worldwide1, it’s an issue sponsors cannot afford to ignore – and with digitally enabled medication adherence packaging, they no longer have to.…

While digital pills have long been hailed as a valuable solution to the stubborn medication adherence problem, there have been questions about their use, in terms of intrusiveness, acceptance, and reliability. But with the evidence base expanding, there are opportunities to embrace the paradigm-shifting potential of this innovative solution. A stubborn challenge It’s no secret…

Even the most efficacious medicines do not work when people don’t take them – and the same is true for digital medication adherence monitoring. Because while the approach has huge potential in clinical trials and routine practice alike, embracing the benefits relies on ensuring solutions are easy to use. A variety of medication adherence monitoring…

Digital health technologies (DHT), including digital medication adherence monitoring, have the potential to revolutionize drug development, and must be given every opportunity to succeed.  That’s according to the European Federation of Pharmaceutical Industries and Associations (EFPIA) reflection paper, which has called for greater clarity and harmonization around how digital solutions fit into the regulatory pathway.…

Drug giant, Pfizer has highlighted the need for effective, patient-centered medication adherence management in clinical trials. Nothing stops a drug from working more than not taking it, but, as medicine and leadership pioneer and Pfizer’s Chief Medical Officer, said, non-adherence in clinical trials damages more than the patient.  “It is also corrosive to the integrity…