"I-TMM maximizes patients� exposure to test drugs, simultaneously maximizing drug response and reducing its variance, and thus increasing statistical power. "

The main features of I-TMM are:

Patient’s drug intakes are electronically monitored by Medication Event Monitoring Systems (MEMS®).
MedAmigo® web-based system provides a view of each patient’s complete dosing history at each visit: the basis to understand the patient’s use of test drugs during trials.
Regular evaluations of the patient’s standing, relative to other trial participants, in respect to regimen execution: a special incentive for low-enders to improve.
Instant, to-the-point suggestions based on patient’s dosing pattern: to focus the dialogue between the patient and the investigator on how best to improve patient’s use of the test drugs.
Updates for trial monitors on each patient’s progress through the trial: summary information to assess center performance and to identify centers that need management support.