Peer reviewed publications 2009-01-01

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AARDEX, established in 1986, has provided MEMS monitors and services to clinical researchers in many universities, research institutes, and pharmaceutical and biotech companies throughout the world. In 2009, our customers have written in peer reviewed publications the following:

• “The MEMS has been regarded as the “reference standard” method for assessing compliance. It is very effective in identifying noncompliance by detecting signal-free periods, and it is the most precise method currently available to track compliance.”
  _{Acosta, F. J., et al.  Schizophr.Res., 107(2): 213-217}.
  
  
• “MEMS is the most widely used electronic monitoring device.”
  _{Christensen, A., L. G. Osterberg, and E. H. Hansen.  J Hypertens 27.8: 1540-51.}
  
  
• “Electronic monitoring is the gold standard in drug trials because it allows the delineation of medication taking dynamics on a day–today basis, reflecting adherence over time (i.e. taking and timing).”
  _{Fine, R. N., et al.  Am J Transplan 9: 35-41.}
  
  
• “… we measured adherence using an electronic monitor, a technique considered to be the most sensitive for nonadherence and the most accurate.”
  _{Gross R., Tierney C., Andrade A., et al.; Arch of Intern Med, 169(13): 1224-1232}.
  
  
• “Electronic Monitoring System. This method employs technical monitors that can provide objective, quantitative estimates and face fewer problems due to confounding by other predictor variables.”
  _{Gwadry-Sridhar, F. H., et al.  Clin Ther 31(2):421-435.}
  
  
• “One method for obtaining accurate outpatient dosing records is the medication event monitoring system (MEMS), an electronic system that has been commercially available since 1989. MEMS detects medication bottle opening and closing over time and records these events. It is one of the most effective indirect methods for accurately determining patient adherence.”
  _{Jin, Y., et al.  J Clin.Pharmacol. 49(2): 176-84.}
  
  
• “As the MEMS is known to be the gold standard for the measurement of adherence, the primary outcome measure was the MEMS and the downloaded data was used to establish if the subjects opened their antidepressant bottle during the prescribed number of times daily.”
  _{Lee, M. S., et al., J Affect.Disord., Nov.}
  
  
• “Electronic monitoring using the Medication Event Monitoring System (MEMS) is widely accepted as the most reliable method for compiling drug dosing histories in ambulatory patients, providing an accurate, objective and up-to-date dosing history of each patient.”
  _{Miki, T., et al. Bone, 44: S95-S95}
  
  
• “Feeback of electronically monitored adherence shows promise as a strategy for increasing medication adherence in adults with asthma and HIV.”
  _{Otsuki, M., et al.  Pediatrics, 124(6): 1513-1521.}
  
  
• “Adherence has been measured with many different techniques, including patient self-report, prescription refills, pill counts during follow-up visits, and measurement of blood levels of pharmaceuticals. However, previous findings indicate that medication event monitoring systems (MEMS) are more accurate than these various techniques at assessing medication adherence, presumably because these MEMS record the exact date and time of medication bottle openings via embedded microprocessor technology.”
  _{Saini, S. D., et al. Am. J. Manag. Care, 15(6): e22-e33.}
  
  
• “In our opinion, electronic monitoring is not only a tool to assess and support patient adherence but also may help clinicians to take more rational therapeutic decisions based on objective data on drug adherence and, eventually, to improve BP control.”
  _{Santschi, V., A. Chiolero, and M. Burnier. J Hypertens., 27(11): 2294-2295}.
  
  
• “Electronic adherence monitoring using MEMS monitors is the most rigorously quantitative measure of adherence available, and it is more sensitive at detecting nonadherence than other commonly used measures.”
  _{Shuter, J., et al.  HIV Clin.Trials 10(3): 135-42.}